反应详情

温度

85 °C

Sodium sulfide nonahydrate (875 mg, 3.78 mmol) and sulfur (120 mg, 3.78 mmol) were heated until molten. The water was driven off with nitrogen to give a solid. The obtained solid was added in portions to N-(2-chloro-5-nitrophenyl)-4-methylbenzamide (1 g, 3.44 mmol) in ethanol (20 mL) at 85° C. The solution was stirred at 85° C. for 3 h. After cooling, 2M aqueous HCl was added, and the solution was extracted three times with ethyl acetate. The combined organic layers were dried over anhydrous MgSO4 and evaporated. The resulting solid was purified by column chromatography eluting with ethyl acetate/hexanes 10:90 v/v to afford 400 mg (43%) of the title compound.

1. customto give a solid
2. temperatureAfter cooling
3. extractionthe solution was extracted three times with ethyl acetate
4. dry with materialThe combined organic layers were dried over anhydrous MgSO4
5. customevaporated
6. customThe resulting solid was purified by column chromatography
7. washeluting with ethyl acetate/hexanes 10:90 v/v