反应详情

A solution of N-ethyl-1,4-dioxaspiro[4.5]decan-8-amine (1.8 g, 9.9 mmol) from above step a in THF is treated with TEA (1.4, 9.9 mmol) and benzyloxycarbonyl chloride (1.4 mL, 9.9 mmol). The mixture was stirred for 18 h at room temperature. THF was removed under vacuum and the residue was taken EtOAc and washed with 10% citric acid, saturated NaHCO3, and saturated NaCl. The solution was dried over Na2SO4 and evaporated under vacuum. The residue was purified by silica column chromatography to give the title compound.

1. customTHF was removed under vacuum
2. washwashed with 10% citric acid, saturated NaHCO3, and saturated NaCl
3. dry with materialThe solution was dried over Na2SO4
4. customevaporated under vacuum
5. customThe residue was purified by silica column chromatography