反应详情

Into a 100 mL round-bottom flask, was placed a solution of tert-butyl 5-oxo-3-(trifluoromethyl)-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate (as prepared in the previous step, 2.7 g, 8.54 mmol, 1.00 equiv) in dichloromethane (20 g) and CF3COOH (4 g). The reaction mixture was stirred for 2 h at room temperature. The pH value of the solution was adjusted to 8 with sodium bicarbonate. The resulting solution was extracted with 3×30 mL of dichloromethane, and the combined organic layers was washed with 1×50 mL of brine, dried over anhydrous sodium sulfate, and concentrated under vacuum. The title compound was obtained a yellow solid.

1. customInto a 100 mL round-bottom flask, was placed
2. extractionThe resulting solution was extracted with 3×30 mL of dichloromethane
3. washthe combined organic layers was washed with 1×50 mL of brine
4. dry with materialdried over anhydrous sodium sulfate
5. concentrationconcentrated under vacuum