HCID 68003845, compound → HCID 68003661, compound

HRID 1896944Notes

Reaction equation

HRID 1896944 reaction equation
[F:1][C:2]([F:23])([F:22])[C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[N:9]=[N:8][CH:7]=[C:6]2[NH:13][CH2:14][C:15]([O:17]C(C)(C)C)=[O:16]>ClCCl.C(O)(C(F)(F)F)=O>[F:23][C:2]([F:1])([F:22])[C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[N:9]=[N:8][CH:7]=[C:6]2[NH:13][CH2:14][C:15]([OH:17])=[O:16]

Participants

4

Reactant 1

HCID 68003845HCID 68003845, compound

Product 1

HCID 68003661HCID 68003661, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 6422Trifluoroacetic acidSolvent

Procedure

Into a 100 mL round-bottom flask, was placed a solution of tert-butyl 2-(6-(trifluoromethyl)cinnolin-4-ylamino)acetate (as prepared in the previous step, 200 mg, 0.61 mmol, 1.00 equiv) in dichloromethane (5 mL) and CF3COOH (0.2 mL). The reaction mixture was stirred overnight at room temperature, and then was concentrated under vacuum. The title compound was obtained as a yellow solid.

Workup

  1. customInto a 100 mL round-bottom flask, was placed
  2. concentrationwas concentrated under vacuum

Sources & evidence

ORD record
ord-36141437251f40a9a55e35731847b948
Source dataset
uspto-grants-2013_08
Patent number
US08518969B2

Reaction notes

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