HCID 58562734, compound → HCID 68003608, compound

HRID 1896950Notes

Reaction equation

HRID 1896950 reaction equation
[F:1][C:2]([F:30])([F:29])[C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[N:9]=[N:8][CH:7]=[C:6]2[NH:13][CH2:14][C:15]([NH:17][CH:18]1[CH2:21][N:20](C(OC(C)(C)C)=O)[CH2:19]1)=[O:16]>ClCCl.C(O)(C(F)(F)F)=O>[NH:20]1[CH2:19][CH:18]([NH:17][C:15](=[O:16])[CH2:14][NH:13][C:6]2[C:5]3[C:10](=[CH:11][CH:12]=[C:3]([C:2]([F:1])([F:30])[F:29])[CH:4]=3)[N:9]=[N:8][CH:7]=2)[CH2:21]1

Participants

4

Reactant 1

HCID 58562734HCID 58562734, compound

Product 1

HCID 68003608HCID 68003608, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 6422Trifluoroacetic acidSolvent

Procedure

Into a 50-mL round-bottom flask, was placed a solution of tert-butyl 3-(2-(6-(trifluoromethyl)cinnolin-4-ylamino)acetamido)azetidine-1-carboxylate (140 mg, 0.33 mmol,) in dichloromethane (10 ml) and CF3COOH (1 ml). The reaction mixture was stirred for 2 h at room temperature. The resulting mixture was concentrated under vacuum to give the title compound as yellow oil.

Workup

  1. customInto a 50-mL round-bottom flask, was placed
  2. concentrationThe resulting mixture was concentrated under vacuum

Sources & evidence

ORD record
ord-469f080e3c014713803c74177ceaea01
Source dataset
uspto-grants-2013_08
Patent number
US08518969B2

Reaction notes

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