Hydrochloric Acid → HCID 66890171, compound

HRID 1897960Notes

Reaction equation

HRID 1897960 reaction equation
[C:1]([N:5]1[C:9]([NH:10][C:11]2[N:16]=[C:15]([CH2:17][C:18]3([C:31]4[O:32][C:33](=[O:36])[NH:34][N:35]=4)[CH2:23][CH2:22][N:21](C(OC(C)(C)C)=O)[CH2:20][CH2:19]3)[CH:14]=[CH:13][CH:12]=2)=[CH:8][CH:7]=[N:6]1)([CH3:4])([CH3:3])[CH3:2].[ClH:37]>CO.O1CCOCC1>[ClH:37].[ClH:37].[C:1]([N:5]1[C:9]([NH:10][C:11]2[N:16]=[C:15]([CH2:17][C:18]3([C:31]4[O:32][C:33](=[O:36])[NH:34][N:35]=4)[CH2:19][CH2:20][NH:21][CH2:22][CH2:23]3)[CH:14]=[CH:13][CH:12]=2)=[CH:8][CH:7]=[N:6]1)([CH3:4])([CH3:2])[CH3:3]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 66889439tert-butyl 4-((6-((1-tert-butyl-1H-pyrazol-5-yl)amino)pyridin-2-yl)methyl)-4-(5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)piperidine-1-carboxylate

Product 1

HCID 66890171HCID 66890171, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 312751,4-DioxaneSolvent

Procedure

To a solution of 250 mg of tert-butyl 4-((6-((1-tert-butyl-1H-pyrazol-5-yl)amino)pyridin-2-yl)methyl)-4-(5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)piperidine-1-carboxylate in 4 ml of methanol was added 4 ml of 4 M hydrogen chloride in 1,4-dioxane at room temperature. The reaction mixture was stirred at room temperature for 1 hour, and concentrated in vacuo to give the title compound as a pale yellow solid.

Workup

  1. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-b2184f9ff760414fa48b591b68b3be70
Source dataset
uspto-grants-2013_08
Patent number
US08519136B2

Reaction notes

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