HCID 57942393, compound → HCID 44178044, compound

HRID 1898200Notes

Reaction equation

HRID 1898200 reaction equation
C(OC([N:8]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[C:10]([N:17]([C:20]([C:22]2[C:27]([NH:28][S:29]([C:32]3[CH:37]=[CH:36][C:35]([Cl:38])=[C:34]([C:39]([F:42])([F:41])[F:40])[CH:33]=3)(=[O:31])=[O:30])=[CH:26][C:25]([Cl:43])=[CH:24][N:23]=2)=[O:21])[CH2:18][CH3:19])=[N:9]1)=O)(C)(C)C>C(Cl)Cl.C(O)(C(F)(F)F)=O>[CH2:18]([N:17]([C:10]1[C:11]2[C:16](=[CH:15][CH:14]=[CH:13][CH:12]=2)[NH:8][N:9]=1)[C:20]([C:22]1[C:27]([NH:28][S:29]([C:32]2[CH:37]=[CH:36][C:35]([Cl:38])=[C:34]([C:39]([F:41])([F:42])[F:40])[CH:33]=2)(=[O:31])=[O:30])=[CH:26][C:25]([Cl:43])=[CH:24][N:23]=1)=[O:21])[CH3:19]

Participants

4

Reactant 1

HCID 57942393HCID 57942393, compound

Product 1

HCID 44178044HCID 44178044, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 6422Trifluoroacetic acidSolvent

Procedure

3-{[5-Chloro-3-(4-chloro-3-trifluoromethyl-benzenesulfonylamino)-pyridine-2-carbonyl]-ethyl-amino}-indazole-1-carboxylic acid tert-butyl ester was dissolved in a mixture of DCM and TFA (1:1) (5 mL). It was stirred at RT for 1 hour, concentrated, purified with HPLC to give 5-chloro-3-(4-chloro-3-trifluoromethyl-benzenesulfonylamino)-pyridine-2-carboxylic acid ethyl-(1H-indazol-3-yl)-amide. MS m/z: 557.9 (M+H)+.

Workup

  1. concentrationconcentrated
  2. custompurified with HPLC

Sources & evidence

ORD record
ord-24fdc2750fbb4d9fb58bbe76cc14ff56
Source dataset
uspto-grants-2013_08
Patent number
US08519135B2

Reaction notes

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