Thiophosgene → 1048919-76-1

HRID 1898306Notes

Reaction equation

HRID 1898306 reaction equation
[CH3:1][C:2]1[C:7]([NH2:8])=[CH:6][CH:5]=[C:4]([CH3:9])[N:3]=1.[C:10](Cl)(Cl)=[S:11].C(N(C(C)C)C(C)C)C>C(Cl)Cl>[N:8]([C:7]1[C:2]([CH3:1])=[N:3][C:4]([CH3:9])=[CH:5][CH:6]=1)=[C:10]=[S:11]

Participants

5

Reactant 3

HCID 10040ThiophosgeneHCID 769642,6-Dimethyl-3-pyridylamineHCID 81531Diisopropylethylamine

Product 1

HCID 451567911048919-76-1Yield 66.4%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound was prepared following the procedure described for intermediate-2 using 2,6-dimethylpyridin-3-amine (1.0 g, 8.26 mmol), thiophosgene (0.949 g, 8.25 mmol) and N-ethyl di-isopropyl amine (3.20 g, 24.80 mmol) in DCM (20 mL) to afford 0.900 g of the desired product. 1HNMR (DMSO-d6): δ 2.44 (s, 6H), 7.18 (d, J=8.1 Hz, 1H), 7.70 (t, J=8.1 Hz, 1H); MS [M+H]+: 165.28.

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-65e99ac6d2ae4cae86c868d9e237e744
Source dataset
uspto-grants-2013_08
Patent number
US08519149B2

Reaction notes

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