反应详情

The title compound was prepared by following the procedure described for Example-108 using 2-[(2-chloro-6-methylphenyl)amino]-7,7-dimethyl-7,8-dihydro-1H-furo[3,2-e]benzimidazole-5-carboxylic acid (Intermediate-35, 0.100 g, 0.268 mmol), thionyl chloride (3.0 mL), 2-fluoro-5-(trifluoromethyl) aniline (0.053 g, 0.296 mmol), THF (10.0 mL) and DIPEA (3 mL). The obtained crude product was purified by column chromatography on neutral alumina eluting with 0.7-1.0% MeOH:DCM to afford 0.014 g of the desired product. 1HNMR (DMSO-d6): δ 1.56 (s, 6H), 2.25 (s, 3H), 3.15 (s, 2H), 7.32 (m, 4H), 7.54 (m, 3H), 8.98 (s, 1H), 10.25 (s, 1H), 11.50 (s, 1H); MS [M+H]+: 533.37.

1. customThe title compound was prepared
2. customThe obtained crude product
3. customwas purified by column chromatography on neutral alumina eluting with 0.7-1.0% MeOH