Thionyl Chloride → HCID 178422735, compound

HRID 1898385Notes

Reaction equation

HRID 1898385 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[NH:9][C:10]1[NH:11][C:12]2[C:18]3[CH2:19][C:20]([CH3:23])([CH3:22])[O:21][C:17]=3[C:16]([C:24]([OH:26])=O)=[CH:15][C:13]=2[N:14]=1.S(Cl)(Cl)=O.[F:31][C:32]([F:44])([F:43])[C:33]1[CH:38]=[CH:37][C:36]([C:39]2([NH2:42])[CH2:41][CH2:40]2)=[CH:35][CH:34]=1.CCN(C(C)C)C(C)C>C1COCC1>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[NH:9][C:10]1[NH:11][C:12]2[C:18]3[CH2:19][C:20]([CH3:23])([CH3:22])[O:21][C:17]=3[C:16]([C:24]([NH:42][C:39]3([C:36]4[CH:37]=[CH:38][C:33]([C:32]([F:31])([F:43])[F:44])=[CH:34][CH:35]=4)[CH2:41][CH2:40]3)=[O:26])=[CH:15][C:13]=2[N:14]=1

Participants

6

Reactant 4

HCID 24386Thionyl ChlorideHCID 81531DiisopropylethylamineHCID 534204531-(4-(Trifluoromethyl)phenyl)cyclopropanamineHCID 178422815HCID 178422815, compound

Product 1

HCID 178422735HCID 178422735, compoundYield 10.1%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The title compound was prepared by following the procedure described for Example-108 using 2-[(2-chloro-6-fluorophenyl)amino]-7,7-dimethyl-7,8-dihydro-1H-furo[3,2-e]benzimidazole-5-carboxylic acid (Intermediate-15, 0.100 g, 0.266 mmol), thionyl chloride (2.0 mL), 1-[4-(trifluoromethyl)phenyl]cyclopropanamine (Intermediate-37, 0.078 g, 0.388 mmol), THF (5.0 mL) and DIPEA (2 mL). The obtained crude product was purified by column chromatography on basic alumina eluting with 0.7-1.0% MeOH:DCM to afford 0.015 g of the desired product. 1HNMR (DMSO-d6): δ 1.38 (d, J=9.0 Hz, 4H), 1.52 (s, 6H), 3.07 (s, 2H), 7.32-7.35 (m, 6H), 7.61-7.64 (m, 2H), 8.39 (s, 1H), 9.20 (s, 1H), 11.0 (s, 1H); MS [M+H]+: 559.25.

Workup

  1. customThe title compound was prepared
  2. customThe obtained crude product
  3. customwas purified by column chromatography on basic alumina eluting with 0.7-1.0% MeOH

Sources & evidence

ORD record
ord-cbc6aca960274548831e258dfc0a3536
Source dataset
uspto-grants-2013_08
Patent number
US08519149B2

Reaction notes

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