Methanesulfonic Acid → HCID 178422769, compound

HRID 1898476Notes

Reaction equation

HRID 1898476 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[NH:9][C:10]1[NH:11][C:12]2[C:18]3[CH2:19][C:20]([CH3:23])([CH3:22])[O:21][C:17]=3[C:16]([C:24]([NH:26][C:27]3[CH:32]=[CH:31][C:30]([C:33]([F:36])([F:35])[F:34])=[CH:29][N:28]=3)=[O:25])=[CH:15][C:13]=2[N:14]=1.[CH3:37][S:38]([OH:41])(=[O:40])=[O:39]>CC(C)=O>[CH3:37][S:38]([OH:41])(=[O:40])=[O:39].[Cl:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[C:3]=1[NH:9][C:10]1[NH:11][C:12]2[C:18]3[CH2:19][C:20]([CH3:22])([CH3:23])[O:21][C:17]=3[C:16]([C:24]([NH:26][C:27]3[CH:32]=[CH:31][C:30]([C:33]([F:36])([F:35])[F:34])=[CH:29][N:28]=3)=[O:25])=[CH:15][C:13]=2[N:14]=1

Participants

4

Reactant 2

HCID 6395Methanesulfonic AcidHCID 178422767HCID 178422767, compound

Product 1

HCID 178422769HCID 178422769, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

The title compound was prepared following the procedure described for Example-169 by using 2-[(2,6-dichlorophenyl)amino]-7,7-dimethyl-N-[5-(trifluoromethyl)pyridin-2-yl]-7,8-dihydro-1H-furo[3,2-e]benzimidazole-5-carboxamide (Example-101, 0.100 g), acetone, methanesulphonic acid to afford 0.059 g of the desired product. 1HNMR (DMSO-d6): δ 1.60 (s, 6H), 2.38 (s, 3H), 3.25 (s, 2H), 7.61 (m, 1H), 7.77 (m, 3H), 8.27 (d, J=7.3 Hz, 1H), 8.46 (d, J=8.7 Hz, 1H), 8.79 (s, 1H), 10.42 (s, 1H), 11.50 (br s, 1H), 13.00 (br s, 2H).

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-eeb124b2b11648b5a958cd223b3fefa9
Source dataset
uspto-grants-2013_08
Patent number
US08519149B2

Reaction notes

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