HRID1898522

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6422

未命名化合物

HCID31268

Pyrrolidine

C4H9N

结构：C[Si](C)(C)CCOCn1cc(C(=O)O)c2nc(C3CC3)cnc21

HCID57829653

未命名化合物

结构：Cn1cc(-c2cnc3c(n2)c(C(=O)O)cn3COCC[Si](C)(C)C)cn1

HCID67008937

未命名化合物

HCID67386173

未命名化合物

PRODUCTS

生成物

结构：Cn1cc(-c2cnc3[nH]cc(C(=O)N[C@@H](C(=O)N4CC[C@@H](C#N)C4)C(C)(C)C)c3n2)cn1

HCID53386252

未命名化合物

PROCEDURE

实验过程

Prepared according to the procedure outlined in Example 1 substituting (R)-pyrrolidine-3-carbonitrile trifluoroacetate for pyrrolidine and 2-(1-methyl-1H-pyrazol-4-yl)-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[3,2-b]pyrazine-7-carboxylic acid for 2-cyclopropyl-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid. Trifluoroacetic acid was used in place of hydrochloric acid for all N-Boc deprotection steps. MS: (M+H)+=435.

WORKUP

后处理

customPrepared

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-b4a097b466604216b3ee0bd018bd2879
来源数据集: uspto-grants-2013_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08518945B2
来源说明: uspto-grants-2013_08

反应 SMILES

F[C:2](F)(F)[C:3]([OH:5])=O.[NH:8]1[CH2:12][CH2:11][C@@H:10]([C:13]#[N:14])[CH2:9]1.[NH:15]1CCCC1.[CH3:20][N:21]1[CH:25]=[C:24]([C:26]2[N:31]=[C:30]3[C:32]([C:43]([OH:45])=O)=[CH:33][N:34](COCC[Si](C)(C)C)[C:29]3=[N:28][CH:27]=2)[CH:23]=[N:22]1.[CH:46]1([C:49]2N=C3C(C(O)=O)=CN(COCC[Si](C)(C)C)C3=NC=2)[CH2:48][CH2:47]1.FC(F)(F)C(O)=O>>[C:13]([C@@H:10]1[CH2:11][CH2:12][N:8]([C:3]([C@H:2]([NH:15][C:43]([C:32]2[C:30]3[C:29](=[N:28][CH:27]=[C:26]([C:24]4[CH:23]=[N:22][N:21]([CH3:20])[CH:25]=4)[N:31]=3)[NH:34][CH:33]=2)=[O:45])[C:46]([CH3:49])([CH3:48])[CH3:47])=[O:5])[CH2:9]1)#[N:14]