3-Amino-1-propanol → HCID 54096213, compound

HRID 1898685Notes

Reaction equation

HRID 1898685 reaction equation
[OH:1][C:2]1[C:3]([CH3:18])=[C:4]2[C:9](=[C:10]([CH3:13])[C:11]=1[CH3:12])[O:8][C:7]([CH3:17])([C:14]([OH:16])=O)[CH2:6][CH2:5]2.C1N=CN(C(N2C=NC=C2)=O)C=1.[NH2:31][CH2:32][CH2:33][CH2:34][OH:35]>>[OH:1][C:2]1[C:3]([CH3:18])=[C:4]2[C:9](=[C:10]([CH3:13])[C:11]=1[CH3:12])[O:8][C:7]([CH3:17])([C:14]([NH:31][CH2:32][CH2:33][CH2:34][OH:35])=[O:16])[CH2:6][CH2:5]2

Participants

4

Reactant 3

HCID 90863-Amino-1-propanolHCID 40634TroloxHCID 682631,1'-Carbonyldiimidazole

Product 1

HCID 54096213HCID 54096213, compoundYield 48.3%

Procedure

Following the amide coupling procedure described in protocol A, 500 mg 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid (2.00 mmol), 357 mg CDI (2.20 mmol) and 165 mg 3-aminopropanol (2.2 mmol) produced 297 mg of 6-hydroxy-N-(3-hydroxypropyl)-2,5,7,8-tetramethylchroman-2-carboxamide as an amorphous white solid.

Sources & evidence

ORD record
ord-6814632d8fe84fcaab3fcd6ca77caf26
Source dataset
uspto-grants-2013_08
Patent number
US08519001B2

Reaction notes

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