2-Methoxyethylamine → HCID 19024024, compound

HRID 1898707Notes

Reaction equation

HRID 1898707 reaction equation
[OH:1][C:2]1[C:3]([CH3:18])=[C:4]2[C:9](=[C:10]([CH3:13])[C:11]=1[CH3:12])[O:8][C:7]([CH3:17])([C:14]([OH:16])=O)[CH2:6][CH2:5]2.C1N=CN(C(N2C=NC=C2)=O)C=1.[CH3:31][O:32][CH2:33][CH2:34][NH2:35]>>[OH:1][C:2]1[C:3]([CH3:18])=[C:4]2[C:9](=[C:10]([CH3:13])[C:11]=1[CH3:12])[O:8][C:7]([CH3:17])([C:14]([NH:35][CH2:34][CH2:33][O:32][CH3:31])=[O:16])[CH2:6][CH2:5]2

Participants

4

Reactant 3

HCID 80182-MethoxyethylamineHCID 40634TroloxHCID 682631,1'-Carbonyldiimidazole

Product 1

HCID 19024024HCID 19024024, compound

Procedure

Following the amide coupling procedure described in protocol A, 499 mg 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid (2.00 mmol), 370 mg CDI (2.28 mmol) and 165.2 mg 2-methoxyethylamine (2.20 mmol) produced 6-hydroxy-N-(2-methoxyethyl)-2,5,7,8-tetramethylchroman-2-carboxamide as a white crystalline solid.

Sources & evidence

ORD record
ord-107af1fe99a9480d8fc233492a6c9b83
Source dataset
uspto-grants-2013_08
Patent number
US08519001B2

Reaction notes

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