HCID 23373069, compound → HCID 57296950, compound

HRID 1898996Notes

Reaction equation

HRID 1898996 reaction equation
[NH2:1][CH2:2][CH2:3][C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([O:14][CH3:15])[C:11]=2[Cl:13])[NH:6][CH:5]=1>C(OC(=O)CC)(=O)CC>[C:10]([CH:2]([NH2:1])[CH2:3][C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([O:14][CH3:15])[C:11]=2[Cl:13])[NH:6][CH:5]=1)(=[O:14])[CH2:9][CH3:8]

Participants

3

Reactant 1

HCID 23373069HCID 23373069, compound

Product 1

HCID 57296950HCID 57296950, compoundYield 200.6%

Reagents, catalysts & solvents 1

HCID 31263Propionic anhydrideSolvent

Procedure

A solution of 3-(2-aminoethyl)-4-chloro-5-methoxy-indole (260 mg, 1.03 mmol) in propionic anhydride (4 ml) was evaporated to dryness in vacuo at 40° C. Purification by chromatography (SiO2 ; EtOAc) gave 3-(2-propionyl-aminoethyl)-4-chloro-5-methoxyindole (290 mg).

Workup

  1. customPurification by chromatography (SiO2 ; EtOAc)

Sources & evidence

ORD record
ord-fb2c406682ed448ba2ed9ea783faa6b8
Source dataset
uspto-grants-1996_11
Patent number
US05571833

Reaction notes

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