反应详情

Reaction of 2-chloro-3-methyl-4-nitrophenol (2.26 g) with neopentyl iodide (4.78 g) in 1-methyl 2-pyrrolidinone (30 ml) in the presence of potassium carbonate (3.34 g) was conducted at 140° C. overnight. The crude product was partitioned between 2M HCl and ethyl acetate, and the organic phase was washed with water, dried (MgSO4) and evaporated to dryness. The residue was chromatographed (SiO2 ; hexane/ether) to give 2-chloro-3-neopentyloxy-6-nitrotoluene as a yellow solid (2.44 g).

1. customThe crude product was partitioned between 2M HCl and ethyl acetate
2. washthe organic phase was washed with water
3. dry with materialdried (MgSO4)
4. customevaporated to dryness
5. customThe residue was chromatographed (SiO2 ; hexane/ether)