Dodecanoyl chloride → HCID 23371134, compound

HRID 1899747Notes

Reaction equation

HRID 1899747 reaction equation
[CH3:1][N:2]([CH3:8])[CH2:3][CH2:4][CH2:5][NH:6][CH3:7].C(N(CC)C(C)C)(C)C.[C:18](Cl)(=[O:30])[CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH3:29].C(=O)(O)[O-].[Na+]>C(Cl)(Cl)Cl>[CH3:1][N:2]([CH3:8])[CH2:3][CH2:4][CH2:5][N:6]([C:18](=[O:30])[CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH3:29])[CH3:7]

Participants

6

Reactant 4

HCID 8166Dodecanoyl chlorideHCID 783021,3-Propanediamine, N1,N1,N3-trimethyl-HCID 81531DiisopropylethylamineHCID 516892Sodium Bicarbonate

Product 1

HCID 23371134HCID 23371134, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

A mixture of 3.89 g. (0.0335 mol) of N,N,N'-trimethyl-1,3-propylenediamine and 4.33 g. (0.0335 mol) of N,N-diisopropylethylamine in 50 mL chloroform was added to 7.33 g. (0.0335 mol) of lauroyl chloride dropwise, on an icebath, and was then reacted for another two hours at room temperature. 75 mL of aqueous sodium bicarbonate was then added to this reaction mixture, and the chloroform layer was separated and washed with 125 mL aqueous sodium bicarbonate followed by 100 mL water. The chloroform layer was then dried (MgSO4) filtered and concentrated in vacuo.

Workup

  1. additionA mixture of 3.89 g
  2. customthe chloroform layer was separated
  3. washwashed with 125 mL aqueous sodium bicarbonate
  4. dry with materialThe chloroform layer was then dried (MgSO4)
  5. filtrationfiltered
  6. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-bfe993beffc1408587ba47bbb8bbb3bb
Source dataset
uspto-grants-1996_11
Patent number
US05573726

Reaction notes

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