反应详情

温度

60 °C

A mixture of 8-hydroxy-2-methylimidazo[1,2-a]pyridine (207 mg), 2,6-dichloro-3-nitrobenzyl bromide (400 mg) and potassium carbonate (580 mg) in N,N-dimethylformamide (8 ml) was stirred for 2 hours at 60° C. The mixture was cooled and diluted with water. The separated oil was extracted with dichloromethane. The organic layer was washed with water, dried, and concentrated in vacuo. The residue was purified by flash chromatography on silica gel to give 8-(2,6-dichloro-3-nitrobenzyloxy)-2-methylimidazo[1,2-a]pyridine (120 mg) as crystals.

1. temperatureThe mixture was cooled
2. extractionThe separated oil was extracted with dichloromethane
3. washThe organic layer was washed with water
4. customdried
5. concentrationconcentrated in vacuo
6. customThe residue was purified by flash chromatography on silica gel