Dodecylamine → 1-Dodecyl-3-(7-methyl-4-chromanon-8-yl)urea

HRID 1900040Notes

Reaction equation

HRID 1900040 reaction equation
[CH2:1]([NH2:13])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12].[CH3:14][C:15]1[C:24]([N:25]=[C:26]=[O:27])=[C:23]2[C:18]([C:19](=[O:28])[CH2:20][CH2:21][O:22]2)=[CH:17][CH:16]=1>C(OCC)(=O)C>[CH2:1]([NH:13][C:26]([NH:25][C:24]1[C:15]([CH3:14])=[CH:16][CH:17]=[C:18]2[C:23]=1[O:22][CH2:21][CH2:20][C:19]2=[O:28])=[O:27])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12]

Participants

4

Reactant 2

HCID 13583DodecylamineHCID 233719147-Methyl-4-chromanon-8-ylisocyanate

Product 1

HCID 867499751-Dodecyl-3-(7-methyl-4-chromanon-8-yl)ureaYield 78.4%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

95 mg of dodecylamine was added to a solution of 100 mg of 7-methyl-4-chromanon-8-ylisocyanate in 5 ml of ethyl acetate, and the mixture was stirred at room temperature for 12 hr. The solvent was removed by distillation under reduced pressure, and the residue was recrystallized from ethyl acetate to afford 150 mg of the intended title compound.

Workup

  1. customThe solvent was removed by distillation under reduced pressure
  2. customthe residue was recrystallized from ethyl acetate

Sources & evidence

ORD record
ord-61e7bb4524f647489de649335518f760
Source dataset
uspto-grants-1996_11
Patent number
US05574061

Reaction notes

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