反应详情

Chloromethyl morpholine-4-carboxylate (1 equiv.) is added to a 0.1M solution of the potassium salt of methacrylic acid (1.1 equiv.) and 18-crown-6 (2/100 equiv.) in DMF at 0° C. After 15 min at 0° C. and a suitable time at elevated temperature the reaction mixture is filtered and concentrated to dryness under reduced pressure. The residue is purified by flash chromatography giving the wanted methacryloyloxymethyl morpholine-4-carboxylate.

1. filtrationa suitable time at elevated temperature the reaction mixture is filtered
2. concentrationconcentrated to dryness under reduced pressure
3. customThe residue is purified by flash chromatography