Methacrylic Acid → HCID 23371993, compound

HRID 1900161Notes

Reaction equation

HRID 1900161 reaction equation
[N:1]1([C:7]([O:9][CH2:10]Cl)=[O:8])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[K].[C:13]([OH:18])(=[O:17])[C:14]([CH3:16])=[CH2:15].C1OCCOCCOCCOCCOCCOC1>CN(C=O)C>[N:1]1([C:7]([O:9][CH2:10][O:18][C:13](=[O:17])[C:14]([CH3:16])=[CH2:15])=[O:8])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1

Participants

6

Reactant 4

HCID 4093Methacrylic AcidHCID 2855718-Crown-6HCID 5462222PotassiumHCID 23371992Chloromethyl 4-morpholinecarboxylate

Product 1

HCID 23371993HCID 23371993, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Chloromethyl morpholine-4-carboxylate (1 equiv.) is added to a 0.1M solution of the potassium salt of methacrylic acid (1.1 equiv.) and 18-crown-6 (2/100 equiv.) in DMF at 0° C. After 15 min at 0° C. and a suitable time at elevated temperature the reaction mixture is filtered and concentrated to dryness under reduced pressure. The residue is purified by flash chromatography giving the wanted methacryloyloxymethyl morpholine-4-carboxylate.

Workup

  1. filtrationa suitable time at elevated temperature the reaction mixture is filtered
  2. concentrationconcentrated to dryness under reduced pressure
  3. customThe residue is purified by flash chromatography

Sources & evidence

ORD record
ord-2308766acdac48bbb0be023c0eb251c8
Source dataset
uspto-grants-1996_11
Patent number
US05574097

Reaction notes

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