反应详情

A solution of 5.2 g (24.6 mmol, 46% strength) of 3-cyano-2,5-dihydrofuran in 50 ml of absolute methylene chloride is mixed with 0.3 g of triethylamine and 0.3 g of trifluoroacetic acid, the mixture is heated under reflux and then 7 g (29.5 mmol) of N-benzyl-N-methoxymethyl-N-(tri-methylsilylmethyl)-amine are added dropwise. Subsequently, the mixture is heated under reflux for 2 hours and the solution is washed with saturated sodium hydrogen carbonate solution, dried over magnesium sulphate, concentrated and distilled.

1. temperaturethe mixture is heated
2. temperatureunder reflux
3. temperatureSubsequently, the mixture is heated
4. temperatureunder reflux for 2 hours
5. washthe solution is washed with saturated sodium hydrogen carbonate solution
6. dry with materialdried over magnesium sulphate
7. concentrationconcentrated
8. distillationdistilled