Hydrochloric Acid → N-(2-Nitrophenyl)-4-(3-trifluoromethylphenyl)-1-piperazinpropionamide

HRID 1900549Notes

Reaction equation

HRID 1900549 reaction equation
Br[CH2:2][CH2:3][C:4]([NH:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[N+:13]([O-:15])=[O:14])=[O:5].[F:16][C:17]([F:31])([F:30])[C:18]1[CH:19]=[C:20]([N:24]2[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]2)[CH:21]=[CH:22][CH:23]=1.Cl>>[N+:13]([C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=1[NH:6][C:4](=[O:5])[CH2:3][CH2:2][N:27]1[CH2:26][CH2:25][N:24]([C:20]2[CH:21]=[CH:22][CH:23]=[C:18]([C:17]([F:30])([F:31])[F:16])[CH:19]=2)[CH2:29][CH2:28]1)([O-:15])=[O:14]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 42961-(3-(Trifluoromethyl)phenyl)piperazineHCID 147625833-bromo-N-(2-nitrophenyl)propionamide

Product 1

HCID 33473794N-(2-Nitrophenyl)-4-(3-trifluoromethylphenyl)-1-piperazinpropionamide

Procedure

The compound was prepared from 3-bromo-N-(2-nitrophenyl)propionamide and 1-(3-trifluoromethylphenyl)piperazine according to the method described in J. Med. Chem. 33, 2970 (1990). Monohydrochloride salt. M.p. 185°-188° C.

Sources & evidence

ORD record
ord-16ee469600994a3cb1576b6769680d05
Source dataset
uspto-grants-1996_11
Patent number
US05576318

Reaction notes

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