Hydrochloric Acid → HCID 15615456, compound

HRID 1900602Notes

Reaction equation

HRID 1900602 reaction equation
[C:1]([NH:4][CH2:5][CH:6]1[CH2:9][N:8](C(C2C=CC=CC=2)C2C=CC=CC=2)[CH2:7]1)(=[O:3])[CH3:2].[ClH:23]>[OH-].[OH-].[Pd+2].C(O)C>[ClH:23].[C:1]([NH:4][CH2:5][CH:6]1[CH2:9][NH:8][CH2:7]1)(=[O:3])[CH3:2]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 23369480HCID 23369480, compound

Product 1

HCID 15615456HCID 15615456, compound

Reagents, catalysts & solvents 2

HCID 9942167Palladium hydroxideCatalystHCID 702EthanolSolvent

Procedure

19.5 g (0.0662 mol) of the compound obtained in stage c), 200 ml of 95% ethanol, 3.91 g of 20% Pd(OH)2 on carbon and 5.4 ml of concentrated hydrochloric acid are charged into a hydrogenation apparatus. They are placed under a hydrogen atmosphere and hydrogenated at ambient pressure, at 40° C., for 3 hours. After filtering, the filtrate is concentrated by evaporation at reduced pressure and the oily residue is taken up with benzene (2×50 ml) and then with acetone. The organic solvent is evaporated at reduced pressure to obtain 10 g of 3-acetylaminomethylazetidine hydrochloride.

Workup

  1. filtrationAfter filtering
  2. concentrationthe filtrate is concentrated by evaporation at reduced pressure
  3. customThe organic solvent is evaporated at reduced pressure

Sources & evidence

ORD record
ord-3b5cb43ff54648b1bd2af47ff2b49846
Source dataset
uspto-grants-1996_11
Patent number
US05576320

Reaction notes

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