Hydrochloric Acid → HCID 18796759, compound

HRID 1900659Notes

Reaction equation

HRID 1900659 reaction equation
C([O:3][C:4](/[C:6](/[CH3:30])=[CH:7]/[C:8]1[N:17]=[C:16]([NH:18][CH2:19][C:20]2[CH:25]=[CH:24][C:23]3[O:26][CH2:27][O:28][C:22]=3[CH:21]=2)[C:15]2[C:10](=[CH:11][CH:12]=[C:13]([Cl:29])[CH:14]=2)[N:9]=1)=[O:5])C.[OH-].[Na+].Cl>O1CCCC1.C(O)C>[C:4](/[C:6](/[CH3:30])=[CH:7]/[C:8]1[N:17]=[C:16]([NH:18][CH2:19][C:20]2[CH:25]=[CH:24][C:23]3[O:26][CH2:27][O:28][C:22]=3[CH:21]=2)[C:15]2[C:10](=[CH:11][CH:12]=[C:13]([Cl:29])[CH:14]=2)[N:9]=1)([OH:5])=[O:3]

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 70108448HCID 70108448, compound

Product 1

HCID 18796759HCID 18796759, compoundYield 92.9%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

1.00 g (0.0023 mol) of (E)-2-(2-ethoxycarbonylpropenyl)-4-(3,4-methylenedioxybenzyl)amino-6-chloroquinazoline was dissolved in a mixture comprising 5 ml of tetrahydrofuran and 20 ml of ethanol, followed by the addition of 20 ml of a 1N aqueous solution of sodium hydroxide. The obtained mixture was stirred at room temperature for several hours, neutralized with 20 ml of 1N hydrochloric acid and concentrated under a reduced pressure. The crystal thus formed was recovered by filtration, washed with water and air-dried to give 0.85 g of the title compound.

Workup

  1. concentrationconcentrated under a reduced pressure
  2. customThe crystal thus formed
  3. filtrationwas recovered by filtration
  4. washwashed with water
  5. customair-dried

Sources & evidence

ORD record
ord-8b87e8a1bb3c4ba288ccc1bd3390b303
Source dataset
uspto-grants-1996_11
Patent number
US05576322

Reaction notes

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