反应详情

3.61 g of methyl isonipecotate, 2.32 g of triethylamine and 5 ml of 2-propanol were added to 1 g of 2,6-dichloro-4-(3,4-methylenedioxybenzyl)aminoquinazoline prepared in Example 92. The obtained mixture was refluxed for 100 minutes. The mixture thus obtained was extracted with chloroform twice. The organic layers were combined, washed with water, dried over magnesium sulfate and freed from the solvent by distillation. The residue was recrystallized (from ethanol/water) to give 1.31 g of the title compound.

1. temperatureThe obtained mixture was refluxed for 100 minutes
2. customThe mixture thus obtained
3. extractionwas extracted with chloroform twice
4. washwashed with water
5. dry with materialdried over magnesium sulfate
6. distillationfreed from the solvent by distillation
7. customThe residue was recrystallized (from ethanol/water)