反应详情

温度

50 °C

Chloroform (1.5 ml) was added to a mixture of 5-hydroxy-6-allyl-8-methylcarbostyril (50.6 mg) and m-chloroperbenzoic acid (61.5 mg). The obtained mixture was stirred at 50° C. for 17 hours. Excessive aqueous sodium sulfite solution was added thereto, and stirring was continued at room temperature for 30 minutes, followed by extracting with a solvent mixture of chloroform and methanol (4:1). The organic phase was dried over sodium sulfate, and condensed. The resultant residue was purified by thin layer chromatography (solvent=chloroform:methanol=10:1), obtaining 20.6 mg of 2-hydroxymethyl-5-methyl-2,3,6,7-tetrahydrofuro[2,3-f]quinoline-7-one (37.9%).

1. stirringstirring
2. waitwas continued at room temperature for 30 minutes
3. extractionby extracting with a solvent mixture of chloroform and methanol (4:1)
4. dry with materialThe organic phase was dried over sodium sulfate, and condensed
5. customThe resultant residue was purified by thin layer chromatography (solvent=chloroform:methanol=10:1)