Hydrochloric Acid → HCID 23369566, compound

HRID 1900783Notes

Reaction equation

HRID 1900783 reaction equation
Cl.[NH2:2][CH2:3][CH:4]1[O:16][C:15]2[C:6](=[C:7]3[C:12](=[C:13]([CH3:17])[CH:14]=2)[NH:11][C:10](=[O:18])[CH:9]=[CH:8]3)[CH2:5]1.[H][H]>O.[Pd]>[NH2:2][CH2:3][CH:4]1[O:16][C:15]2[C:6](=[C:7]3[C:12](=[C:13]([CH3:17])[CH:14]=2)[NH:11][C:10](=[O:18])[CH2:9][CH2:8]3)[CH2:5]1

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 23369590HCID 23369590, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 23369566HCID 23369566, compoundYield 63.6%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 962WaterSolvent

Procedure

A hydrochloric acid salt of 2-aminomethyl-5-methyl-1,2-dihydrofuro-[3,2-f]quinoline-7-one (1.0 g) was dissolved in water (50 ml). To the solution, 10% palladium-on-carbon (1 g) was added, followed by stirring at 80° C. for 1.5 hours in the atmosphere of hydrogen. After the catalyst was removed by filtration, the mixture was condensed. The resultant residue was recrystallized from methanol--ether to obtain 642 mg of a hydrochloric acid salt of 2-aminomethyl-5-methyl-1,2,8,9-tetrahydrofuro-[3,2-f]quinoline-7-one as colorless prisms (63.7%).

Workup

  1. customAfter the catalyst was removed by filtration
  2. customcondensed
  3. customThe resultant residue was recrystallized from methanol

Sources & evidence

ORD record
ord-66a67d928caa4feb8222460eb76c2777
Source dataset
uspto-grants-1996_11
Patent number
US05576324

Reaction notes

Loading…