Hydrochloric Acid → HCID 67748597, compound

HRID 1901078Notes

Reaction equation

[ClH:1].[CH3:2][O:3][C:4](=[O:34])[C@H:5]([CH2:30][CH2:31][S:32][CH3:33])[NH:6][C:7](=[O:29])[C:8]1([CH2:21][C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=2[CH3:28])[CH2:13][CH2:12][N:11](C(OC(C)(C)C)=O)[CH2:10][CH2:9]1>CCOC(C)=O>[ClH:1].[CH3:2][O:3][C:4](=[O:34])[C@H:5]([CH2:30][CH2:31][S:32][CH3:33])[NH:6][C:7](=[O:29])[C:8]1([CH2:21][C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=2[CH3:28])[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1

Participants

Conditions

Temperature: 0 °C

Procedure

A stream of anhydrous HCl gas was bubbled through a cold (0° C.) solution of (N-t-butoxycarbonyl-4-(2-methylbenzyl) isonipecotyl) L-methionine methyl ester (315 mg, 0.66 mmol) in 30 ml of EtOAc for 10 min. and the reaction solution stirred 1 h more at 0° C. The solution was then purged with argon for 10 min. and allowed to warm to room temp. Concentration of the solution in vacuo afforded the product as a colorless gum.

Workup

customThe solution was then purged with argon for 10 min.
temperatureto warm to room temp

Sources & evidence

ORD record: ord-5b4f2d35de37425f9cd09b05a0a5440d
Source dataset: uspto-grants-1996_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05576313

Reaction notes

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