Dimethylformamide → HCID 21832160, compound

HRID 1901194Notes

Reaction equation

HRID 1901194 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](C)(O)[C:9]([O:11]C)=O)=[CH:4][CH:3]=1.Br[CH2:16][C:17](=[O:19])[CH3:18].[C:20](=[O:23])([O-])[O-:21].[K+].[K+].[CH3:26]N(C)C=O>>[O:19]=[C:17]([CH3:18])[CH2:16][O:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][CH:9]([OH:11])[C:20]([O:21][CH3:26])=[O:23])=[CH:6][CH:7]=1

Participants

5

Reactant 4

HCID 6228DimethylformamideHCID 11430Potassium CarbonateHCID 11715BromoacetoneHCID 572033HCID 572033, compound

Product 1

HCID 21832160HCID 21832160, compound

Procedure

Following a procedure similar to that described in Preparation 3, but using 1.8 g of methyl 4-hydroxyphenyllactate, 1.63 g of bromoacetone, 1.65 g of potassium carbonate and 150 ml of dimethylformamide, the title compound was obtained having an Rf=0.32 (thin layer chromatography over silica gel, using a 1:1 by volume mixture of hexane and ethyl acetate as the developing solvent).

Workup

  1. customthat described in Preparation 3

Sources & evidence

ORD record
ord-37de65fa956446b7abdd2e89ae06e61c
Source dataset
uspto-grants-1996_11
Patent number
US05576340

Reaction notes

Loading…