Tyrosol → 2-[4-(2-Oxopropoxy)phenyl]ethanol

HRID 1901195노트

반응식

HRID 1901195 반응식
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][OH:10])=[CH:4][CH:3]=1.Br[CH2:12][C:13](=[O:15])[CH3:14].C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[O:15]=[C:13]([CH3:14])[CH2:12][O:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][OH:10])=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 10393TyrosolHCID 11430Potassium CarbonateHCID 11715Bromoacetone

생성물 1

HCID 218321652-[4-(2-Oxopropoxy)phenyl]ethanol

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

Following a procedure similar to that described in Preparation 3, but using 10 g of 2-(4-hydroxyphenyl)-ethanol, 21.6 g of bromoacetone, 30 g of potassium carbonate and 100 ml of dimethylformamide, the title compound was obtained having an Rf=0.31 (thin layer chromatography over silica gel, using a 1:1 by volume mixture of hexane and ethyl acetate as the developing solvent).

후처리

  1. customthat described in Preparation 3

출처 및 근거

ORD 기록
ord-f844bf5cf29d49ef93d3b36ff7fddb07
출처 데이터셋
uspto-grants-1996_11
특허 번호
US05576340

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