Potassium Carbonate → HCID 21832142, compound

HRID 1901204Notes

Reaction equation

HRID 1901204 reaction equation
[CH2:1]([O:3][C:4]([C:6]([C:23]1[CH:28]=[CH:27][C:26]([OH:29])=[CH:25][CH:24]=1)([C:18]([O:20][CH2:21][CH3:22])=[O:19])[CH:7]([C:13]([O:15][CH2:16][CH3:17])=[O:14])[C:8]([O:10][CH2:11][CH3:12])=[O:9])=[O:5])[CH3:2].Br[CH2:31][C:32](=[O:34])[CH3:33].C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[CH2:21]([O:20][C:18]([C:6]([C:23]1[CH:28]=[CH:27][C:26]([O:29][CH2:31][C:32](=[O:34])[CH3:33])=[CH:25][CH:24]=1)([C:4]([O:3][CH2:1][CH3:2])=[O:5])[CH:7]([C:13]([O:15][CH2:16][CH3:17])=[O:14])[C:8]([O:10][CH2:11][CH3:12])=[O:9])=[O:19])[CH3:22]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 11715BromoacetoneHCID 12858906HCID 12858906, compound

Product 1

HCID 21832142HCID 21832142, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Following a procedure similar to that described in Preparation 3, but using 11.7 g of p-[1,1,2,2-tetrakis(ethoxycarbonyl)ethyl]phenol, 7.9 g of bromoacetone, 7.9 g of potassium carbonate and 100 ml of dimethylformamide, and then purifying the reaction product by column chromatography through silica gel, using a 1:2 by volume mixture of ethyl acetate and hexane as the eluent, the title compound was obtained having an Rf=0.21 (thin layer chromatography over silica gel, using a 1:2 by volume mixture of ethyl acetate and hexane as the developing solvent).

Workup

  1. customthat described in Preparation 3
  2. custompurifying the reaction product by column chromatography through silica gel
  3. additionby volume mixture of ethyl acetate and hexane as the eluent

Sources & evidence

ORD record
ord-551409a87c15413e87cb48fb6bc8b994
Source dataset
uspto-grants-1996_11
Patent number
US05576340

Reaction notes

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