Hydrochloric Acid → Methyl 6-aminohexanoate hydrochloride

HRID 1901409Notes

Reaction equation

HRID 1901409 reaction equation
[ClH:1].[NH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][C:8]([OH:10])=[O:9].[CH3:11]O>>[ClH:1].[NH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][C:8]([O:10][CH3:11])=[O:9]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 5646-Aminohexanoic AcidHCID 887Methanol

Product 1

HCID 11499324Methyl 6-aminohexanoate hydrochlorideYield 99%

Procedure

Hydrogen chloride (gas) was added to a solution of 20.0 g (152 mmol) of 6-aminocaproic acid in 250 ml of methanol via rapid bubbling for 2-3 minutes. The mixture was stirred at 15°-25° C. for 3 hours and then concentrated to afford 27.5 g of the product as a white solid (99%):

Workup

  1. customvia rapid bubbling for 2-3 minutes
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-61d19d3f790f4d868c962515aceaa300
Source dataset
uspto-grants-1996_11
Patent number
US05578287

Reaction notes

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