Hydrochloric Acid → HCID 86750025, compound

HRID 1901410Notes

Reaction equation

HRID 1901410 reaction equation
Cl.[Br:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][C:8]([OH:10])=[O:9].[CH3:11]O>>[CH3:11][CH:7]([CH2:6][CH2:5][CH2:4][CH2:3][Br:2])[C:8]([OH:10])=[O:9].[Br:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][C:8]([O:10][CH3:11])=[O:9]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 202106-Bromohexanoic acid

Product 1

HCID 86750025HCID 86750025, compoundYield 90%

Procedure

Hydrogen chloride (gas) was added to a solution of 5.01 g (25.7 mmol) of 6-bromocaproic acid in 250 ml of methanol via vigorous bubbling for 2-3 minutes. The mixture was stirred at 15°-25° C. for 3 hours and then concentrated to afford 4.84 g of the product as a yellow oil (90%):

Workup

  1. customvia vigorous bubbling for 2-3 minutes
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-eb9a9e990b7f4503a9072978612a0aba
Source dataset
uspto-grants-1996_11
Patent number
US05578287

Reaction notes

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