Hydrochloric Acid → 3-(2-Amino-3-ureidocarbonyloxypropoxy)-5-chloro-1,2-benzisoxazole hydrochloride

HRID 1901609Notes

Reaction equation

HRID 1901609 reaction equation
[NH:1]([C:5]([O:7][CH2:8][CH:9]([NH:22]C(OC(C)(C)C)=O)[CH2:10][O:11][C:12]1[C:16]2[CH:17]=[C:18]([Cl:21])[CH:19]=[CH:20][C:15]=2[O:14][N:13]=1)=[O:6])[C:2]([NH2:4])=[O:3].CC(O)C.Cl>CO.C(Cl)(Cl)Cl>[ClH:21].[NH2:22][CH:9]([CH2:8][O:7][C:5]([NH:1][C:2]([NH2:4])=[O:3])=[O:6])[CH2:10][O:11][C:12]1[C:16]2[CH:17]=[C:18]([Cl:21])[CH:19]=[CH:20][C:15]=2[O:14][N:13]=1

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 3776IsopropanolHCID 23368381HCID 23368381, compound

Product 1

HCID 233685053-(2-Amino-3-ureidocarbonyloxypropoxy)-5-chloro-1,2-benzisoxazole hydrochloride

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 6212ChloroformSolvent

Procedure

3-(3-Ureidocarbonyloxy-2-tert-butoxycarbonylaminopropoxy)-5-chloro-1,2-benzoisoxazole is suspended in 10 ml of methanol and 5 ml of chloroform, and 12.8 ml of a 2-propanol solution (7.5N) of hydrogen chloride is added, after which they are subjected to reaction at 20°-25° C. overnight. The crystals precipitated are collected by filtration, to obtain 0.62 g of colorless, crystalline 3-(2-amino-3-ureidocarbonyloxypropoxy)-5-chloro-1,2-benzisoxazole hydrochloride having a melting point of 203°-204° C.

Workup

  1. customafter which they are subjected to reaction at 20°-25° C. overnight
  2. customThe crystals precipitated
  3. filtrationare collected by filtration

Sources & evidence

ORD record
ord-7d62c36d63dd446bafdd7fb1f9bc6c84
Source dataset
uspto-grants-1996_11
Patent number
US05578627

Reaction notes

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