Hydrochloric Acid → HCID 23368376, compound

HRID 1901631Notes

Reaction equation

HRID 1901631 reaction equation
[NH2:1][CH:2]([C:15]1[CH:20]=[CH:19][CH:18]=[C:17]([OH:21])[CH:16]=1)[CH2:3][O:4][C:5]1[C:9]2[CH:10]=[C:11]([Cl:14])[CH:12]=[CH:13][C:8]=2[O:7][N:6]=1.CC(O)C.Cl>C(O)C>[ClH:14].[NH2:1][CH:2]([C:15]1[CH:20]=[CH:19][CH:18]=[C:17]([OH:21])[CH:16]=1)[CH2:3][O:4][C:5]1[C:9]2[CH:10]=[C:11]([Cl:14])[CH:12]=[CH:13][C:8]=2[O:7][N:6]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3776IsopropanolHCID 23368377HCID 23368377, compound

Product 1

HCID 23368376HCID 23368376, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 0.62 g of 3-[2-amino-2-(3-hydroxyphenyl)ethoxy]-5-chloro-1,2-benzoisoxazole in 15 ml of ethanol is added 1.5 ml of a 2-propanol solution (6.5M) of hydrogen chloride at room temperature, and thereafter, the crystals precipitated are collected by filtration and then dried to obtain 0.45 g of colorless, crystalline 3-[2-amino-2-(3-hydroxyphenyl)ethoxy]-5-chloro-1,2-benzoisoxazole hydrochloride having a melting point of 240.5°-243.4° C.

Workup

  1. customthe crystals precipitated
  2. filtrationare collected by filtration
  3. customdried

Sources & evidence

ORD record
ord-be7bc2f1cb7b4fcc88ec1b7d1ea9c089
Source dataset
uspto-grants-1996_11
Patent number
US05578627

Reaction notes

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