1-Azido-3-phenylpropan-2-ol → 1-Amino-3-phenylpropan-2-ol

HRID 1901679Notes

Reaction equation

HRID 1901679 reaction equation
[C:1]1([CH2:7][CH:8]([OH:13])[CH2:9][N:10]=[N+]=[N-])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>O1CCCC1>[C:1]1([CH2:7][CH:8]([OH:13])[CH2:9][NH2:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 137648321-Azido-3-phenylpropan-2-olHCID 21226445Aluminium lithium hydride

Product 1

HCID 37580461-Amino-3-phenylpropan-2-olYield 102.7%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A procedure similar to that described in Preparation 13 was repeated, except that 6.0 g of 3-phenyl-2-hydroxypropylazide (prepared as described in Preparation 16), 2.6 g of lithium aluminum hydride and 300 ml of anhydrous tetrahydrofuran were used, to give 5.26 g of the title compound, melting at 64° C. to 66° C.

Workup

  1. customA procedure similar to that described in Preparation 13

Sources & evidence

ORD record
ord-6c6509b68988429fab355a67dd68e532
Source dataset
uspto-grants-1996_11
Patent number
US05578620

Reaction notes

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