Aluminium lithium hydride → HCID 21474756, compound

HRID 1901713Notes

Reaction equation

HRID 1901713 reaction equation
[C:1]1([CH2:7][CH2:8][CH2:9][CH2:10][O:11][CH2:12][CH:13]([OH:18])[CH2:14][N:15]=[N+]=[N-])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>O1CCCC1>[C:1]1([CH2:7][CH2:8][CH2:9][CH2:10][O:11][CH2:12][CH:13]([OH:18])[CH2:14][NH2:15])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 21474770HCID 21474770, compound

Product 1

HCID 21474756HCID 21474756, compoundYield 96.1%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A procedure similar to that described in Preparation 13 was repeated, except that 4.30 g of 3-(4-phenylbutoxy)-2-hydroxypropylazide (prepared as described in Preparation 59), 1.31 g of lithium aluminum hydride and 120 ml of anhydrous tetrahydrofuran were used, to give 3.70 g of the title compound as a colorless oil having an Rf value of 0.08 (on silica gel thin layer chromatography, using a 10:1 by volume mixture of ethyl acetate and methanol as the developing solvent).

Workup

  1. customA procedure similar to that described in Preparation 13

Sources & evidence

ORD record
ord-ddd8fc3dea184bb195e30b7a7db63b53
Source dataset
uspto-grants-1996_11
Patent number
US05578620

Reaction notes

Loading…