Aluminium lithium hydride → 1-Amino-2-phenylthio-2-propanol

HRID 1901736Notes

Reaction equation

HRID 1901736 reaction equation
[C:1]1([S:7][CH2:8][CH:9]([OH:14])[CH2:10][N:11]=[N+]=[N-])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>O1CCCC1>[C:1]1([S:7][CH2:8][CH:9]([OH:14])[CH2:10][NH2:11])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 214747633-Phenylthio-2-hydroxypropylazide

Product 1

HCID 1137321-Amino-2-phenylthio-2-propanolYield 97.1%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A procedure similar to that described in Preparation 13 was repeated, except that 8 g of 3-phenylthio-2-hydroxypropylazide (prepared as described in Preparation 86), 2.9 g of lithium aluminum hydride and 400 ml of anhydrous tetrahydrofuran were used, to give 6.8 g of the title compound, melting at 57° C. to 61° C.

Workup

  1. customA procedure similar to that described in Preparation 13

Sources & evidence

ORD record
ord-079868872b804ada9b447e99b25724fd
Source dataset
uspto-grants-1996_11
Patent number
US05578620

Reaction notes

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