Hydrochloric Acid → HCID 9908181, compound

HRID 1901950Notes

Reaction equation

HRID 1901950 reaction equation
[CH:1]1[CH:2]=[CH:3][C:4]([C@@H:7]([NH2:24])[C:8]([NH:10][C@@H:11]2[C:18](=[O:19])[N:17]3[C@@H:12]2[CH2:13][CH2:14][C:15]([Cl:23])=[C:16]3[C:20]([OH:22])=[O:21])=[O:9])=[CH:5][CH:6]=1.C[O-].[ClH:27]>C(O)CC>[CH:1]1[CH:2]=[CH:3][C:4]([C@@H:7]([NH2:24])[C:8]([NH:10][C@@H:11]2[C:18](=[O:19])[N:17]3[C@@H:12]2[CH2:13][CH2:14][C:15]([Cl:23])=[C:16]3[C:20]([OH:22])=[O:21])=[O:9])=[CH:5][CH:6]=1.[ClH:27]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86750036HCID 86750036, compound

Product 1

HCID 9908181HCID 9908181, compound

Reagents, catalysts & solvents 1

HCID 10311-PropanolSolvent

Procedure

Loracarbef methanolate (5 g) is added to 50 ml of 1-propanol and 1.34 ml of concentrated hydrochloride acid. The solution is stirred at room temperature for approximately 45 minutes and is stripped to solids and placed in the freezer, with large rhomboid crystals formed. The mixture is dried overnight at room temperature in a vacuum oven and the crystals yellowed. The weight yield is 5.16 grams and the X-ray diffraction pattern of the titled product above is as follows:

Workup

  1. customformed
  2. customThe mixture is dried overnight at room temperature in a vacuum oven

Sources & evidence

ORD record
ord-85d9a4d1655d4beca15d492ea9d0227a
Source dataset
uspto-grants-1996_11
Patent number
US05578720

Reaction notes

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