Acetone → HCID 12893005, compound

HRID 1902181Notes

Reaction equation

HRID 1902181 reaction equation
[CH2:1]([O:3][C:4]1[CH:5]=[C:6]([N:11]2[C:16](=[O:17])[CH:15]3[CH2:18][CH2:19][CH2:20][C:13](=[CH:14]3)C2=O)[CH:7]=[CH:8][C:9]=1[Cl:10])[CH3:2].[CH2:22]([NH:24][CH2:25][CH3:26])[CH3:23].C[C:28](C)=[O:29]>>[CH2:22]([N:24]([CH2:25][CH3:26])[C:28](=[O:29])[C:18]1[CH2:19][CH2:20][CH2:13][CH2:14][C:15]=1[C:16]([NH:11][C:6]1[CH:7]=[CH:8][C:9]([Cl:10])=[C:4]([O:3][CH2:1][CH3:2])[CH:5]=1)=[O:17])[CH3:23]

Participants

4

Reactant 3

HCID 180Acetone2×HCID 8021DiethylamineHCID 20515764HCID 20515764, compound

Product 1

HCID 12893005HCID 12893005, compound

Procedure

To 50 ml of acetone is added 3.0 g of N-(3-ethoxy-4-chlorophenyl)-3,4,5,6-tetrahydroisophthalimide and a solution of 0.8 g of diethylamine in 5 ml of acetone is dropwise added to the solution over the period of about 3 minutes under stirring at room temperature. The solution is stirred at room temperature for a further 4 hours and the solvent is distilled off under reduced pressure for concentration, and recrystallization of the resultant residue from n-hexane yields 2.2 g of the subject compound.

Workup

  1. stirringThe solution is stirred at room temperature for a further 4 hours
  2. distillationthe solvent is distilled off under reduced pressure for concentration, and recrystallization of the resultant residue from n-hexane

Sources & evidence

ORD record
ord-7ffd1d6a550d4154afbf860896e1fcbd
Source dataset
uspto-grants-1982_12
Patent number
US04362546

Reaction notes

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