Hydrochloric Acid → HCID 12837729, compound

HRID 1902196Notes

Reaction equation

HRID 1902196 reaction equation
[CH2:1]1[CH:6]2[C:7]3[N:8]([CH:16]=[CH:17][CH:18]=3)[CH2:9][C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=3[N:5]2[CH2:4][CH2:3][NH:2]1.Cl.[O-:20][C:21]#[N:22].[Na+].O1CCCC1>O>[C:21]([N:2]1[CH2:3][CH2:4][N:5]2[C:11]3[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=3[CH2:9][N:8]3[CH:16]=[CH:17][CH:18]=[C:7]3[CH:6]2[CH2:1]1)(=[O:20])[NH2:22]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 8028TetrahydrofuranHCID 517096Sodium CyanateHCID 12837720HCID 12837720, compound

Product 1

HCID 12837729HCID 12837729, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

To the mixture of 100 mg of 1,3,4,14b-tetrahydro-2H,10H-pyrazino[1,2-a]pyrrolo[2,1-c][1,4]-benzodiazepine, 1 ml of N hydrochloric acid and 10 ml of water, the solution of 54.5 mg of sodium cyanate in 2 ml of water is added while stirring followed by 2 ml of tetrahydrofuran. After stirring overnight at room temperature, it is extracted with methylene chloride, the extract washed with saturated aqueous sodium carbonate, dried and evaporated, to yield the 2-carbamoyl-1,3,4,14b-tetrahydro-10H-pyrazino[1,2-a]pyrrolo[2,1-c][1,4]-benzodiazepine melting at 175°-177°.

Workup

  1. stirringAfter stirring overnight at room temperature
  2. extractionit is extracted with methylene chloride
  3. washthe extract washed with saturated aqueous sodium carbonate
  4. customdried
  5. customevaporated

Sources & evidence

ORD record
ord-ebb097a879a3449cada1ffa92527205a
Source dataset
uspto-grants-1982_12
Patent number
US04362666

Reaction notes

Loading…