反应详情

15.4 parts of 3-trifluoromethylbenzoyl fluoride are added to a stirred mixture of 13.3 parts of 6-methylanthranilic acid and 16.3 parts of tri-n-butylamine in 250 parts of 1,2-dichloropropane at 20°-25° C., and stirring is continued for 20 minutes. The precipitate formed is filtered off and washed with 1 N hydrochloric acid and then with water; the organic filtrate is washed similarly, dried and evaporated down. 27 parts of N-(3'-trifluoromethylbenzoyl)-6-methylanthranilic acid, of melting point 198°-204° C., are obtained.

1. customThe precipitate formed
2. filtrationis filtered off
3. washwashed with 1 N hydrochloric acid
4. washthe organic filtrate is washed similarly
5. customdried
6. customevaporated down