Acetic Acid → HCID 20515434, compound

HRID 1902479Notes

Reaction equation

HRID 1902479 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[NH:8][C:9]1[CH:13]=[C:12]([CH3:14])[N:11]([CH3:15])[C:10]=1[C:16]([O:18]CC)=O.[Na].C(O)(=O)C>C(O)C>[CH3:15][N:11]1[C:10]2[C:16](=[O:18])[NH:1][C:2]3[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=3[NH:8][C:9]=2[CH:13]=[C:12]1[CH3:14]

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 5360545SodiumHCID 20515452HCID 20515452, compound

Product 1

HCID 20515434HCID 20515434, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2.73 g (0.01 mole) of ethyl 3-(2-aminophenyl)amino-1,5-dimethyl-1H-pyrrole-2-carboxylate in a solution of 0.25 g (0.011 mole) of sodium in 40 ml of dry ethanol are boiled under reflux for 2 hours. After the mixture has cooled, it is neutralized carefully with acetic acid; the solvent is stripped off in vacuo, and the yellowish residue is recrystallized from dioxane. Yield: 1.9 g.

Workup

  1. temperatureunder reflux for 2 hours
  2. temperatureAfter the mixture has cooled
  3. customthe yellowish residue is recrystallized from dioxane

Sources & evidence

ORD record
ord-7d9bc16a46834b4ba8f3575b028c767c
Source dataset
uspto-grants-1982_12
Patent number
US04363816

Reaction notes

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