Sodium hydride → HCID 20515479, compound

HRID 1902482Notes

Reaction equation

HRID 1902482 reaction equation
[H-].[Na+].[CH2:3]([O:5][C:6](=[O:15])[CH2:7][N:8]([CH:10]=[C:11]([C:13]#[N:14])[CH3:12])[CH3:9])[CH3:4]>CN(C)C=O>[NH2:14][C:13]1[C:11]([CH3:12])=[CH:10][N:8]([CH3:9])[C:7]=1[C:6]([O:5][CH2:3][CH3:4])=[O:15]

Participants

4

Reactant 2

HCID 24758Sodium hydrideHCID 53785525HCID 53785525, compound

Product 1

HCID 20515479HCID 20515479, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
30 °C

Procedure

300 mg of 80% sodium hydride are added with stirring at 20° C. to a solution of 9.1 g of N-(2-cyano-1-propenyl)sarcosine ethyl ester (obtained by reacting methacrylonitrile with bromine and subsequent reaction with sarcosine ethyl ester) in 50 ml of anhydrous dimethyl formamide. After warming the reaction mixture to 30° C., an exothermic reaction starts (the temperature rises to 45° C.); this reaction is terminated after 30 minutes. The resulting solution of the title compound (b.p. 70° C., 1.3 Pa) is subsequently processed without further purification.

Workup

  1. customan exothermic reaction
  2. customrises to 45° C.
  3. customthis reaction is terminated after 30 minutes
  4. customThe resulting solution of the title compound (b.p. 70° C., 1.3 Pa) is subsequently processed without further purification

Sources & evidence

ORD record
ord-1b48121af48c4fdd87c9fc709d6a1485
Source dataset
uspto-grants-1982_12
Patent number
US04363816

Reaction notes

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