反应详情

19.0 g of 2-[2,6-dichloro-3-methoxyphenyl)imino]-1-hydroxyimidazolidine hydrochloride are suspended in 160 ml of toluene. There are added thereto successively 40 ml of a 40 percent solution of tetra-n-butylammonium hydroxide, 12.2 g of 2-chloromethyl-pyridine N-oxide and 250 ml of a saturated potassium carbonate solution. After 4 hours, the precipitated material is removed by filtration, washed with water and subsequently with ether and recrystallized from chloroform and ethanol. There is obtained 2-([{2-[(2,6-dichloro-3-methoxyphenyl)-imino]-1-imidazolidinyl}oxy]methyl)-pyridine 1-oxide of melting point 199°-200° C. The corresponding dihydrobromide melts with decomposition at 192° (methanol/acetonitrile).

1. additionThere are added
2. customthe precipitated material is removed by filtration
3. washwashed with water and subsequently with ether
4. customrecrystallized from chloroform and ethanol