Hydrazine hydrate (1:1) → 4-Pentyl-3-fluoroanisole

HRID 1902903Notes

Reaction equation

HRID 1902903 reaction equation
[C:1]([C:7]1[CH:12]=[CH:11][C:10]([O:13][CH3:14])=[CH:9][C:8]=1[F:15])(=O)[CH2:2][CH2:3][CH2:4][CH3:5].O.NN.OC(O)C>>[CH2:1]([C:7]1[CH:12]=[CH:11][C:10]([O:13][CH3:14])=[CH:9][C:8]=1[F:15])[CH2:2][CH2:3][CH2:4][CH3:5]

Participants

4

Reactant 3

HCID 24654Hydrazine hydrate (1:1)HCID 1512111,1-EthanediolHCID 205142734-Valeryl-3-fluoroanisole

Product 1

HCID 205142784-Pentyl-3-fluoroanisole

Procedure

4-Valeryl-3-fluoroanisole (14.1 g), hydrazine hydrate (8.6 ml) potassium hydroxide (4.4 g) and 1:1 dihydroxyethane (84 ml) were reacted together as described in Example 1. 4-Pentyl-3-fluoroanisole was isolated as a colourless oil b.pt 77° C. at 0.1 mm. The product showed 1 spot only on tlc using dichloromethanepetrol (1:1) as solvent.

Sources & evidence

ORD record
ord-b14077b30c89452d8b052ebadd29d10c
Source dataset
uspto-grants-1982_12
Patent number
US04366330

Reaction notes

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