反应详情

To 75 ml of isopropanol is added 3.3 g (0.017 m) methyl 3-(2,3-dihydroxypropyl)amino-2-butenoate (3), 4.18 g (0.02 m) 5,6-dichloro-3-nitropyrazinamine (5), and 2.0 g (0.02 m) triethylamine. This solution is heated at 60°-65° for two days. The reaction mixture is then stripped on the rotary evaporator and the residue chromatographed on silica gel eluted with 12% methanol/chloroform. Material with Rf =0.5 is collected and after crystallization from acetonitrile the desired product is an orange solid, m.p. 184°-186° (dec).

1. temperatureThis solution is heated at 60°-65° for two days
2. customThe reaction mixture is then stripped on the rotary evaporator
3. customthe residue chromatographed on silica gel
4. washeluted with 12% methanol/chloroform
5. customMaterial with Rf =0.5 is collected
6. customafter crystallization from acetonitrile the desired product