Sodium Carbonate → HCID 20468252, compound

HRID 1903135Notes

Reaction equation

HRID 1903135 reaction equation
[NH:1]1[CH2:6][CH2:5][CH2:4][CH:3]([C:7]2[CH:15]=[CH:14][CH:13]=[C:12]3[C:8]=2[CH2:9][C:10](=[O:16])[NH:11]3)[CH2:2]1.[CH2:17](I)[CH2:18][CH3:19].C(=O)([O-])[O-].[Na+].[Na+]>>[CH2:17]([N:1]1[CH2:6][CH2:5][CH2:4][CH:3]([C:7]2[CH:15]=[CH:14][CH:13]=[C:12]3[C:8]=2[CH2:9][C:10](=[O:16])[NH:11]3)[CH2:2]1)[CH2:18][CH3:19]

Participants

4

Reactant 3

HCID 10340Sodium CarbonateHCID 336431-IodopropaneHCID 15614163HCID 15614163, compound

Product 1

HCID 20468252HCID 20468252, compound

Procedure

1,3-dihydro-4-(piperidin-3-yl)-2H-indole-2-one and n-propyl iodide in dimethylformaimide were reacted in the presence of sodium carbonate to obtain 1,3-dihydro-4-(1-propyl-piperidin-3-yl)-2H-indole-2-one. A solution of the latter in ether was admixed with an ether solution saturated with hydrogen chloride and the recovered product after crystallization from an isopropanol-methanol mixture melted at 260° C.

Sources & evidence

ORD record
ord-0aefc65851fe4af2ad3d9ceeccb29dc6
Source dataset
uspto-grants-1984_03
Patent number
US04435408

Reaction notes

Loading…