Dimethylformamide → HCID 20468178, compound

HRID 1903198Notes

Reaction equation

HRID 1903198 reaction equation
CN(C)C=O.[CH2:6]([N:13]1[C:23]2[C:18](=[CH:19][C:20]([OH:24])=[CH:21][CH:22]=2)[CH2:17][CH2:16][C:14]1=[O:15])[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.C([O-])([O-])=O.[K+].[K+].[CH2:31]([N:33]([CH2:41][CH:42]1[CH2:47][CH2:46][CH2:45][CH2:44][O:43]1)[C:34](=[O:40])[CH2:35][CH2:36][CH2:37][CH2:38]Cl)[CH3:32]>C(Cl)(Cl)Cl.CO>[CH2:6]([N:13]1[C:23]2[C:18](=[CH:19][C:20]([O:24][CH2:38][CH2:37][CH2:36][CH2:35][C:34]([N:33]([CH2:41][CH:42]3[CH2:47][CH2:46][CH2:45][CH2:44][O:43]3)[CH2:31][CH3:32])=[O:40])=[CH:21][CH:22]=2)[CH2:17][CH2:16][C:14]1=[O:15])[C:7]1[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=1

Participants

7

Reactant 4

HCID 6228DimethylformamideHCID 11430Potassium CarbonateHCID 20468180HCID 20468180, compoundHCID 54008488HCID 54008488, compound

Product 1

HCID 20468178HCID 20468178, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 6212ChloroformSolvent2×

Procedure

Into 50 ml of dimethylformamide were added 1.9 g of 1-benzyl-6-hydroxy-3,4-dihydrocarbostyril, 1.8 g of K2CO3 and 0.5 g of KI. The mixture was heated at 60°-70° C. under stirring, then 3.4 g of N-ethyl-N-(2-tetrahydropyranylmethyl)-5-chloropentanic acid amide was added dropwise gradually thereto. After the addition operation, the reaction mixture was further stirred at the same temperature for 4 hours. Then the solvent was removed by distillation and the residue thus obtained was dissolved in 200 ml of chloroform and the chloroform layer was washed with a diluted hydrochloric acid, 1% NaOH aqueous solution and water in this order, then dried with anhydrous sodium sulfate. The drying agent was removed by filtratoon, and the mother liquor was concentrated, then the residue thus obtained was treated by a silica-gel column chromatography [solvent used was a mixture of chloroform:methanol=20:1 (v/v)]. 0.6 Grams of 1-benzyl-6-{4-[N-(2-tetrahydropyranylmethyl)-N-ethylaminocarbonyl]butoxy}-3,4-dihydrocarbostyril was obtained as in the form of a colorless syrupy substance.

Workup

  1. temperatureThe mixture was heated at 60°-70° C.
  2. stirringAfter the addition operation, the reaction mixture was further stirred at the same temperature for 4 hours
  3. customThen the solvent was removed by distillation
  4. customthe residue thus obtained
  5. washthe chloroform layer was washed with a diluted hydrochloric acid, 1% NaOH aqueous solution and water in this order
  6. dry with materialdried with anhydrous sodium sulfate
  7. customThe drying agent was removed by filtratoon
  8. concentrationthe mother liquor was concentrated
  9. customthe residue thus obtained
  10. additionwas treated by a silica-gel column chromatography [solvent

Sources & evidence

ORD record
ord-9ef257de176646d09241f62e6b23a622
Source dataset
uspto-grants-1984_03
Patent number
US04435404

Reaction notes

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