Trifluoroacetic acid → HCID 13300632, compound

HRID 1903210Notes

Reaction equation

HRID 1903210 reaction equation
FC(F)(F)C(O)=O.[BH4-].[Na+].[Cl:10][C:11]1[C:24]([C:25](=O)[C:26]2[CH:31]=[CH:30][C:29]([OH:32])=[CH:28][CH:27]=2)=[CH:23][C:14]2[CH2:15][CH:16]([C:18]([O:20][CH2:21][CH3:22])=[O:19])[O:17][C:13]=2[C:12]=1[Cl:34]>C(Cl)Cl>[Cl:10][C:11]1[C:24]([CH2:25][C:26]2[CH:27]=[CH:28][C:29]([OH:32])=[CH:30][CH:31]=2)=[CH:23][C:14]2[CH2:15][CH:16]([C:18]([O:20][CH2:21][CH3:22])=[O:19])[O:17][C:13]=2[C:12]=1[Cl:34]

Participants

5

Reactant 3

HCID 6422Trifluoroacetic acidHCID 4311764Sodium borohydrideHCID 13300597HCID 13300597, compound

Product 1

HCID 13300632HCID 13300632, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To trifluoroacetic acid (120 ml.) under a nitrogen atmosphere were added sodium borohydride pellets (5.39 g.) over a period of 30 minutes at 5° C. A solution of ethyl 6,7-dichloro-2,3-dihydro-5-(p-hydroxybenzoyl)-benzofuran-2-carboxylate (7.35 g.) in methylene chloride (50 ml.) was then added dropwise over 30 minutes, and the mixture stirred at room temperature for 22 hours.

Sources & evidence

ORD record
ord-acb8a165402a412fb0c0f2bf95450dc1
Source dataset
uspto-grants-1984_03
Patent number
US04435422

Reaction notes

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